Oxidant Sensing by Reversible Disulfide Bond Formation
نویسندگان
چکیده
منابع مشابه
Oxidant sensing by reversible disulfide bond formation.
Maintenance of the cellular redox balance is crucial for cell survival. An increase in reactive oxygen, nitrogen, or chlorine species can lead to oxidative stress conditions, potentially damaging DNA, lipids, and proteins. Proteins are very sensitive to oxidative modifications, particularly methionine and cysteine residues. The reversibility of some of these oxidative protein modifications make...
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are members of the thioredoxin superfamily and exert their action by a disulfide exchange reaction utilizing a Cys-X1-X2-Cys active site. Other members of the thioredoxin superfamily are responsible for the introduction and isomerization of disulfide bonds that are often presFredrik Åslund† and Jon Beckwith* Department of Microbiology and Molecular Genetics Harvard Medical School 200 Longwood A...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2013
ISSN: 0021-9258
DOI: 10.1074/jbc.r113.462929